For instance, HtrA3 is downregulated in B-cell and T-cell acute lymphoblastic leukemia and acute myeloid leukemia, yet HtrA3 is significantly increased in acute lymphoblastic leukemia where chromosome translocation has occurred at 11q23/MLL or TCF3/PBX1 [117]. The gene discussed is TCF3; the disease is acute lymphoblastic leukemia.