Our recent publications reported that liver-specific deficiency of BAP31 induced Sterol regulatory element binding protein 1 (SREBP1) signaling activation, promoted liver steatosis and worsened insulin resistance in high-fat diet (HFD)-induced obese mice; and increased tunicamycin-induced ER stress reduced the rate of fatty acid oxidation, which promoted tunicamycin-induced liver steatosis, along with increased liver injury markers of serum alanine transaminase (ALT) and aspartate transaminase (AST) in both animal models [9,10]. The gene discussed is SREBF1; the disease is Insulin resistance.