Clonal hematopoiesis of indeterminate potential (CHIP) in leukemia associated genes including DNMT3A, ASXL1, TET2 with a variant allele frequency (VAF) of ≥2% can confer a predisposition for hematological malignancy including overt leukemia, as well as thrombosis, stroke and cardiovascular events [61,62,63,64]. This evidence concerns the gene ASXL1 and leukemia.