PLOD1 and hypoalphalipoproteinemia, primary, 1: These results support the hypothesis that in humans ALC is effective in modulating LH response to GnRH, facilitating LH synthesis, storage and secretion from the pituitary [30,42], since previous reports demonstrated that ALC was able to blunt the negative effect of β-endorphin circadian rhythms in rats exposed to different stressors [40] and was able to increase gonadotropin content in the pituitary and both gonadotropin plasma levels and gonadotropin response to GnRH stimulation test in patients with FHA [42].