Although LPA is known to elicit cellular responses through various signaling pathways [19], ROCK, STAT3, p38 MAPK, and PI3K/AKT pathways are specifically involved in LPA-induced proliferation in various cell types, such as corneal endothelial cells, colorectal cancer cells, and renal mesangial cells [27,30,39]. The gene discussed is AKT1; the disease is colorectal cancer.