5-HT6R antagonists were shown to be effective in paradigms of episodic (NOR test) and spatial working memory (mazes or spontaneous alternation tasks), social cognition, and executive functions (set-shifting or reversal learning tasks) and in preventing memory impairments induced by scopolamine, phencyclidine (PCP), MK-801, ketamine, streptozotocin, as well as age-associated impairments (reviewed in [15,41,42,43,44]). This evidence concerns the gene HTR6 and age.