BRAF and colorectal carcinoma: Protein-protein interaction (PPI) network was constructed from down-regulated proteins and enriched with AKT and ERK1/2 as known biomarkers of acquired resistance to PLX4032 in BRAFV600E mutant CRC (Supplementary Figure S2), and BRAF and SPHK2 as specific pharmacological targets of PLX4032 and ABC294640, respectively.