Among cytokines, chemokine (C-C motif) ligand 2 (CCL2), also named monocyte chemoattractant protein 1 (MCP1), is produced by tumor cells and by various other cells in the host microenvironment, including adipocytes, and was reported upregulated in various tumors, including CRC, and in obesity [11,12]. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.