SOCS1 and lobular neoplasia: miR-150 is upregulated in the kidney tissue in LN patients, particularly in proximal renal tubular cells but also in mesangial cells and podocytes, and promotes renal fibrosis by downregulating suppressor of cytokine signal 1 (SOCS1) and increasing expression of profibrotic factors including fibronectin, COL1, COL3 and TGF-β1 [77,78].