This study again suggests strongly that modulation of P2X family receptor signaling might be a particularly effective method to reduce NLRP3 inflammasome activation that leads to the signaling cascades that govern solid organ allograft rejection, and that the P2X7-NLRP3 activation pathway in particular is conserved in other non-transplant-related autoimmune disorders. Here, NLRP3 is linked to Autoimmunity.