Additionally, a recent study in adipose tissue insulin resistance in response to statin therapy has implicated dysregulation in protein prenylation via statin activation of p38 upstream of IL-1β, which led to priming of NLRP3 inflammasomes in macrophages, even in mice lacking IL-1β, and promoted subsequent lack of prenylation and increased insulin resistance [34]. Here, IL1B is linked to Insulin resistance.