GSDMD and myocardial infarction: However, TAK1 signaling has also been associated a more nuanced effect in a rat model of myocardial infarction—it was found that NLRP3 inflammasome hyperactivation was associated with the death of cardiomyocytes by gasdermin D (GSDMD)-dependent pyroptosis and that TAK1/JNK1 signaling was an effective promoter of this hyperactivation [27].