Moreover, researchers presented that the expression of VISTA in GC is correlated not only with PD-L1 expression but also with Epstein–Barr virus infection, tumor localization, Lauren phenotype, and KRAS-and PIK3CA-mutational status, while no correlation exists between the expression of VISTA with tumor stage, distant metastasis, and lymph node metastasis. Here, PIK3CA is linked to neoplasm.