ANG and amyotrophic lateral sclerosis: Accordingly, mutations of the gene encoding for ANG have been found in patients affected by neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) [57] and Parkinson’s disease (PD) [58], while an increased concentration of ANG has been measured in patients with ulcerative and Crohn’s diseases (CrD) [59].