The main mechanism of the proangiogenic properties of CCL2/MCP-1 is the recruitment of monocytes into the tumor niche, which are transformed into TAM [206,207], which secrete VEGF-A but also other proangiogenic factors such as matrix metalloproteinase 9 (MMP-9) and PGE2 [208]. Here, MMP9 is linked to neoplasm.