SIRT1 and myelodysplastic syndrome: Among the epigenetic genes downregulated by ABT-737 treatment, we mostly found factors associated with gene repression, including genes either involved in DNA methylation (Dnmt3A and B, Tet 1 and 3), histone methylation (Dotl1, Ehmt2, Kmt2) and histone deacetylation (Hdac 1, 2,4,5 and 10 and Sirt1), features usually associated with HR-MDS pathogenesis.