For instance, it will be fundamental to understand: (i) the cause-effect relationships between neuroinflammation/autophagy and those additional, still unknown, pathways that are perhaps under the control of P2X7 in ALS; (ii) the specific contribution to ALS of each P2X7-bearing cell phenotype and, particularly, the efficacy of a central versus peripheral cell-specific modulation of P2X7; (iii) the most appropriate timing and dosing for improving the therapeutic effectiveness in ALS through early versus late P2X7 modulation; and (iv), the role possibly played by P2X7 in additional ALS models. This evidence concerns the gene P2RX7 and amyotrophic lateral sclerosis.