CYP2E1 and infectious otitis media: The catalytic activity of CYP2E1 in liver microsomes (two-way ANOVA, N = 8/group) suggested that dietary selenium affected catalytic activity of CYP2E1 in both untreated (Figure 2a) and AOM/DSS-treated (Figure 2b) animals, with a visible decrease in CYP2E1 activity at adequate and high selenium levels.