SELENOF and malignant colon neoplasm: These results agreed with the findings in cell culture, where a targeted down-regulation of Selenof expression resulted in a reversal of the colon cancer phenotype: reduced cell proliferation, reduced ability to grow anchorage-independently, with a concomitant increase in expression of IFN-γ-regulated guanylate binding protein (GBP)-1 [17,18,26].