Overall, modest increases in circulating IFN-γ, IL-10, IL-12p70, IL-1β, C-X-C motif ligand 1 (CXCL1), and tumor necrosis factor (TNF)-α were observed in WT and Selenof-KO mice when treated with AOM/DSS in comparison to their untreated controls, respectively. The gene discussed is CXCL1; the disease is infectious otitis media.