Asymptomatic hypoglycemia (plasma glucose < 3.9 mmol/L), symptomatic hypoglycemia (plasma glucose < 3.0 mmol/L), and severe hypoglycemia (SH, plasma glucose not defined, a circumstance where the patient is unconscious and requires the assistance of someone else) are frequent in patients with T1D and T2D who use insulin, or in T2D patients on sulfonylureas [1]. The gene discussed is INS; the disease is type 2 diabetes mellitus.