TNF and Alzheimer disease: In another model of AD mice, induced by co-administration of D-galactose and aluminium chloride, supplementation with DHA (200 mg/kg) + EGb761 (Ginkgo biloba standardized extract) enhanced behavioral recovery and protein phosphatase 2A expression, a major protein phosphatase of tau in the brain, while it downregulated TNF-α expression (both in the hippocampus, CA3) [39].