APP and Alzheimer disease: Oridonin, a natural diterpenoid compound isolated from the Chinese herb Rabdosia rubescens, was loaded into commercial lipid nanocarriers, Lipofundin® (MCT, 10% for infusion, B. Braun AG, Melsungen, Germany), and then given orally or injected into mice constituting an animal model of cerebral amyloidosis for AD, transgenic APP/PS1 mice.