A clinical study including 129 HCC patients showed that the levels of serum lncRNA were highly upregulated in liver cancer (HULC); metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), Linc00152, pituitary tumor-transforming 3 pseudogene (PTTG3P), SPRY4 intronic transcript 1 (SPRY4-IT1), ubiquitin-conjugating enzyme E2C pseudogene 3 (UBE2CP3), and urothelial carcinoma-associated 1 (UCA1) were significantly higher in HCC patients than in benign liver disease patients and healthy controls [72]. This evidence concerns the gene SPRY4 and hepatocellular carcinoma.