In contrast to the abovementioned lncRNAs, lncRNA carbamoyl-phosphate synthetase 1 intronic transcript 1 (CPS1-IT1) levels were obviously decreased in HCC, while CPS1-IT1 overexpression reduced HIF-1α activation to inhibit EMT and metastasis [138]. The gene discussed is CPS1; the disease is hepatocellular carcinoma.