Furthermore, lncRNA MALAT1 [152] targets miR-140 to upregulate VEGF-A expression and lncRNA MYLK Antisense RNA 1 (MYLK-AS1) [48] binds to miR-424-5p to increase the levels of E2F transcription factor 7 (E2F7) to activate the VEGFR-2 signaling pathway, which facilitates HCC progression and angiogenesis. This evidence concerns the gene E2F7 and hepatocellular carcinoma.