It was reported that myocardin was SUMOylated by SUMO1 in K445, and SUMOylation of myocardin by SUMO1 and E3 PIAS1 reversed the expression of myocardial genes and enhanced the cardiac hypertrophy of primary neonatal cardiomyocytes [74]. The gene discussed is SUMO1; the disease is cardiac hypertrophy.