Accumulating evidence indicates that phosphofructokinase 1 (PFK1), hexokinase 2 (HK2), and pyruvate kinases type M2 (PKM2) are critically involved in aerobic glycolysis in HCC in association with other signaling networks such as the PI3K/Akt/mTOR pathway, HIF-1α, c-Myc, AMPK, and noncoding RNAs [10]. This evidence concerns the gene PFKM and hepatocellular carcinoma.