An earlier study reported that blocking of integrin β1 inhibited the active TGF-β1 mediated MAP kinase activation [33], while our data suggests that the integrin β1 alters TGF-β receptor-2 and kindlin2 expression in pancreatic cancer and downregulates Smad2/3 phosphorylation. The gene discussed is SMAD2; the disease is pancreatic neoplasm.