In addition, tumor volumes were significantly increased in KO mice (3882.06 ± 1313.67 mm3) compared to the CO animals (2298.31 ± 1094.59 mm3; n = 16/group, p= 0.006; Figure 1), along with increased local invasiveness (i.e., disruption of the tumor capsule; 14/16 in KO and 6/16 in WT; p < 0.01), suggesting that a reduced MCT2 expression promoted increased tumor growth and regional invasiveness. This evidence concerns the gene SLC16A7 and neoplasm.