However, on closer inspection of the individual prostate cancer baseline samples as presented in Figure 3, fold changes exceeding 1 were deemed to be significant, with CDKN1A, FDXR and SESN1 exceeding this threshold fold change particularly for 0.5 Gy for all 3 genes with PCNA in contrast below the threshold. The gene discussed is SESN1; the disease is Familial prostate cancer.