Additionally, E-selectin overexpression and the subsequent interaction with the tumor-microenvironment was shown to activate pro-survival and antiapoptotic signaling via the ERK/AKT, PI3K, NF-κB, or Wnt pathway (reviewed in [134]), which promoted tumor progression, chemoresistance [134], and also the maintenance of cancer cell stemness [141]. This evidence concerns the gene AKT1 and neoplasm.