PPAR-related effects on tumour development have historically been linked to cell-cycle blockade genes such as p18, p21, and p27, leading to apoptosis through the inhibition of B-cell lymphoma 2 (Bcl-2) and reduced angiogenesis through the inhibition of vascular endothelial growth factor (VEGF) [48,49]. Here, VEGFA is linked to neoplasm.