The coinjection of SHG44 and U251 cells with exosomes from SNHG16-overexpressing CSCs into nude mice promoted glioma progression, whereas the inoculation with SHG44 and U251 transfected with si-TLR7 or si-MyD88 reverted those effects by decreasing NFκB activity and c-Myc expression. The gene discussed is MYD88; the disease is central nervous system cancer.