CXCL8 and neoplasm: MSCs, under stimulation with CSC-derived EVs, showed an increased expression of MMP1 and MMP3, genes associated with cell migration such as CXC chemokine receptor type (CXCR4, CXCR7); matrix remodeling such as collagen, type IV, alpha 3 (COL4A3); angiogenesis; and tumor growth such as interleukin 8 (IL-8), osteopontin, and myeloperoxidase.