The coinjection of SHG44 and U251 cells with exosomes from SNHG16-overexpressing CSCs into nude mice promoted glioma progression, whereas the inoculation with SHG44 and U251 transfected with si-TLR7 or si-MyD88 reverted those effects by decreasing NFκB activity and c-Myc expression. This evidence concerns the gene MYC and central nervous system cancer.