A study by Conigliaro et al. concerning hepatocarcinoma [129] also revealed that exosomes from liver CSCs stimulated the angiogenic phenotype and cell-to-cell adhesion in HUVECs through the transfer of long intergenic non-protein-coding RNA 8 (lncRNA H19), thus demonstrating the key role of lncRNA H19 in tumor angiogenesis and suggesting it as a putative therapeutic target in hepatocellular carcinoma. This evidence concerns the gene H19 and neoplasm.