In vivo, the treatment with OV, alone or in combination with cisplatin, was able to reduce the oncogenicity of tumorspheres, also decreasing the content of PI3K, STAT3, mTOR, TGF-β1, and miR-21-5p in CSC-EVs of tumor samples explanted from OV-treated mice. The gene discussed is STAT3; the disease is neoplasm.