The frequency of the SERPINA1 MS genotype differed neither in the ALD and NASH subgroup nor in the pooled other subgroup of cases from the frequency in the controls (9 of 327; 2.75%; 4 of 125; 3.2%; 19 of 569; 3.34% vs. 101 of 3240; 3.12%; N.S. for all). This evidence concerns the gene SERPINA1 and metabolic dysfunction-associated steatohepatitis.