SERPINA1 and cirrhosis of liver: When evaluating the genotype frequency in the subgroups of cases according to the liver cirrhosis aetiology, the frequency of the SERPINA1 MZ genotype carriers was significantly higher in the subgroups of cases with ALD and NASH cirrhosis (24 of 360; 6.67% and 16 of 125; 12.8%, respectively, p < 0.001 for both) than in the controls (87 of 3,240; 2.69%).