Of particular interest was the down-regulation of proteins specifically associated with neurodegenerative diseases such as the microtubule (MT)-associated protein tau (MAPT) [35], Cu/Zn superoxide dismutase (SOD1) [36,37] and the mitochondrial transcription factor A (TFAM) [38], as well as several components of the proteasome. Here, TFAM is linked to neurodegenerative disease.