On the other hand, various function molecules such as tocopherol (for pH-triggered polymeric micelles) [75], biotin (for anti-heparanase activity to treat multiple myeloma) [76], chlorambucil (as a redox-responsive prodrug) [77], suramin fragment (to enhance or mimic heparin’s properties) [78,79], and the thiol group (for pH and GSH dual-responsive carriers for inhibiting tumor growth) [80] were recently conjugated to heparin molecules as new therapeutic biomolecules; they are currently under evaluation. Here, HPSE is linked to neoplasm.