APOE and neoplasm: Moreover, referring the internalization of the cTBSV NPs to TBSV-RGD (a well characterized tumor-targeting peptide) [13], it was observed that the uptake of TBSV-tLyp1 and -CooP was increased by 1.43 and 1.78 times, respectively, while the internalization efficiency of TBSV-RiGiD and -ApoE was reduced (0.54 and 0.59 times respectively).