Figure 1 shows the proposed model, taking into account division into particular modules: (a) SARS-CoV-2 infection and related subprocesses (orange); (b) RAA: renin–angiotensin–aldosterone system (yellow); (c) inflammation and lymphocytes activation (green); (d) endothelial dysfunction (dark purple); (e) oxidative stress (dark blue); (f) role of nitric oxide (light blue); (g) extra-renal sodium retention (pink); (h) chronic kidney disease (light purple). The described model is available in the Supplementary Materials. The gene discussed is REN; the disease is endothelial dysfunction.