Consistent with our findings of the elevated IL-8/MCP-1 expression in obese states and its association with the systemic inflammation (CRP), Kim et al. found the increased circulating levels of IL-8 and MCP-1 and their positive association with obesity-related parameters including BMI, HOMA, and CRP [14]. The gene discussed is CXCL8; the disease is obesity due to melanocortin 4 receptor deficiency.