PRKDC was upregulated by 2.12-fold in ADPKD tissue (95% CI (1.78, 2.53); q < 0.001), increasing from 1.41-fold in minimally cystic tissue (95% CI (1.13, 1.76); q < 0.05) to 3.18-fold in large cysts (95%CI (1.41, 4.47); q < 0.05). Here, PRKDC is linked to autosomal dominant polycystic kidney disease.