Moreover, a possible angiogenetic role of miR-21 could be speculated: Liu and colleagues found that miR-21 induces vascular endothelial growth factor (VEGF)-mediated tumour angiogenesis through targeting phosphatase and tensin homolog (PTEN) and activation of AKT/ERK signalling [38,39]. The gene discussed is AKT1; the disease is neoplasm.