ORM1 and type 2 diabetes mellitus: Dos Santos Nunes and colleagues investigated the methylation profile of MTHFR gene promoter and its relationship with biochemical (glycemia, glycated haemoglobin, and lipid level), inflammatory (C-reactive protein and alpha-1 acid glycoprotein) and oxidative stress markers (total antioxidant and malonaldehyde) in Brazilian T2D patients affected or not by DR [56].