The main oncogenic mutation of BRAF occurs when the valine amino acid in position 600 is replaced by glutamic acid to produce V600EBRAF, which is the major mutation in melanomas [16,17,18,19,20] and papillary thyroid carcinomas [10], accounting for up to 63% in melanoma and 50% in papillary thyroid carcinomas. The gene discussed is BRAF; the disease is thyroid gland papillary carcinoma.