Following validation by qPCR analysis in independent samples consisting of 25 sporadic and 12 hereditary parathyroid tumors, and 24 normal parathyroid tissues, only miR-199b-5p was significantly found downregulated and negatively correlated with PTH levels in the sporadic tumors and upregulated in the hereditary forms compared with its expression in normal tissues. The gene discussed is PTH; the disease is tumor of parathyroid gland.