Several publications report (i) high RBP4 concentration in plasma or high levels of RBP4 mRNA in adipose tissue of obese, diabetic individuals and their close relatives [20,21]; (ii) a positive association between serum RBP4, insulin resistance and adiposity [20,22]; (iii) a negative association (or inverse correlation) between serum RBP4 and HDL levels [20]. The gene discussed is RBP4; the disease is Insulin resistance.