Furthermore, RBP4 gene expression in human adipose tissue and heart positively correlates with expression of inflammatory markers such as the mannose receptor C-type 1 (MRC1), C-C motif chemokine ligand 18 (CCL18) or Toll-like receptor 4 (TLR4), and with cardiac hypertrophy markers such as the natriuretic peptides [25,26]. This evidence concerns the gene TLR4 and cardiac hypertrophy.