In line with the functional role of αEβ7 highlighted by all these studies, administration of a monoclonal antibody against αEβ7 (Table 1) was able to reduce the accumulation of CD4+ T cells in the lamina propria and their IFNγ production, thus ameliorating immunization-induced colitis in the IL2 knockout mouse model [63]. Here, CD4 is linked to colitis.