ATP2A2 and dentin dysplasia: In DD and HHD, mutations in the ATP2A2 and AT+-P2C1 Ca2+ pump genes cause damaged desmosome/(corneo)desmosome formation [32,33,37]; however, clinical signs usually appear after adolescence and nearly always in SGR/AGR areas despite being present throughout the lifetime and in all keratinocytes [32,36,37].