IFNG and acute coronary syndrome: Furthermore, pro-inflammatory cytokines known as key factors for PSO lesions development, IFN-γ (interferon gamma), TNF-α (tumor necrosis factor alfa) and IL-17, were found in increased amounts in unstable atherosclerotic plaques in patients with acute coronary syndromes, whereas cardiovascular biomarkers such as MCP-1 (monocyte chemoattractant protein) as well as macrophage-derived chemokines were measured in skin and serum in PSO patients [91,92,93].