CD8A and neoplasm: Our results have shown that the level of tumor-infiltrating TIGIT+CD8+ T-cells is significantly associated the inferior OS and RFS of affected patients (HR = 2.17, 95% CI: 1.43–3.29, and p-value < 0.001, and HR = 1.89, 95% CI: 1.3–2.63, and p-value < 0.001, respectively) (Figure 5).