In particular, Narayan and coworkers applied a SILAC approach to quantitatively analyze the proteome of fibroblasts from ALS patients and matched controls, thus identifying 33 proteins differentially regulated, among which ApoB48, Hsp20 and Fibulin-1 were proposed as novel biomarkers and therapeutic targets [32]. This evidence concerns the gene FBLN1 and amyotrophic lateral sclerosis.