Similarly to the above studies conducted in healthy women, long-term intranasal oxytocin (32 IU) and placebo in a randomized, prospective, double-blind, placebo-controlled, crossover that lasted 22 weeks were both found to be able to ameliorate sexual activity and depression symptoms in women over time with no treatment, sequence (placebo first/second), or interaction effect [315]. Here, OXT is linked to major depressive disorder.