OXT and major depressive disorder: Intranasal oxytocin has also been found to be ineffective in modifying sexual arousal, orgasm, and the parameters of appetitive, consummatory, and refractory sexual behavior determined together with partner interactions in a double-blind, placebo-controlled cross-over design in healthy women [312] and was unable to improve sexual activity and depression symptoms when chronically administered in women over time [315,327].