MLH1 and neoplasm: Furthermore, multiple alterations in the DNA methylation pattern of promoters of genes involved in cell cycle regulation, such as CDKN2A-p16INK4a, tumor suppression including RB, VHL or epithelial membrane protein 3 (EMP3), DNA repair and genome integrity (e.g., MGMT and hMLH1) as well as genes associated with the regulation of tumor invasion and inhibition of apoptosis, such as DAPK1, TIMP3, CDH1, PCDHGA11 and TMS1/ASC have been also found as epigenetic alterations presented in gliomas [15,16].