Moreover, we (3) found elevated AK4 levels in α-SMA-positive cells in remodeled pulmonary vessels from IPAH patients, and reduced proliferation and glycolytic metabolism of IPAH-PASMCs after AK4 knockdown, supporting a potential in vivo role of AK4 in the process of pulmonary vascular remodeling. The gene discussed is AK4; the disease is idiopathic pulmonary arterial hypertension.