FUT8 and cancer: Changes in N- and O-glycosylation is well studied and have been reported in many cancer EVs, such as altered glycosylation of O-glycans is a characteristic change in the mucins, which dissipates the normal maturation of the glycans and leads to the overexpression of Thomsen-Friedenreich-related T, Tn, and STn antigens [27], while aberrant glycosylation of N-glycans, proximal fucosylation, and the corresponding enzyme FUT8 are upregulated in several types of cancer.