In addition, loss of PHLDA3 in MIN6 cells (mouse pancreatic islet cells), was shown to lead to activation of PI3K/Akt/mTOR pathway and hyperplasia, as also demonstrated by the administration in PHLDA3-deficient mice of streptozotocin, inducing apoptosis in pancreatic islet cells, which ultimately resulted as resistant but without tumor appearance [26]. Here, PHLDA3 is linked to neoplasm.