The T1 groups included functional neoplasias with no variants in ATRX, DAXX, and MEN1 as opposed to the T2 group, also characterized by larger size, longer telomeres, diffuse chromosomal LOH unrelated to the methylation levels, a high tumor mutational burden (especially in the mTOR pathway), and lower methylation of MGMT. The gene discussed is MGMT; the disease is neoplasm.