On the other hand, it has been found that from day 9 of the cancer cell inoculation in-to the tibia medulla, there was an increased expression of both the protein HMGB1 and the IL-1β in the spinal dorsal horn that correlated with the loss and destruction of the bone and with a progressive allodynia to pressure stimulation in the ipsilateral inoculated hind paw. The gene discussed is HMGB1; the disease is cancer.