Moreover, in a transgenic mouse model of RA that overexpresses TNF, infliximab also improved arthritic symptoms and neurological function [97], and the use of another anti-TNF mAb, adalimumab, reduced signs of inflammation and edema of the affected joints, in addition to decreasing the morphological signs of the disease and of the expression of TNF in a rat model of RA induced by CFA [98]. Here, TNF is linked to rheumatoid arthritis.