In the first decade of the 2000s, there were several clinical studies that investigated the effectiveness of anti-TNF therapy (infliximab, etanercept, and adalimumab) in CLBP with or without radiculopathy, or sciatica [17], but randomized controlled trials and a meta-analysis failed to demonstrate the superiority of anti-TNF vs. placebo [128,129,130]. Here, TNF is linked to radiculopathy.