HMMR and cancer: In terms of cellular functions, RHAMM/HA interactions have been shown to regulate cell motility [11,12], myofibroblast activation into a pro-fibrosis state [90,91,92], macrophage chemotaxis and pro-inflammatory activation [92,93], adipogenesis [90,91,94], fibroblast neoplastic transformation [5], and cancer cell proliferation and survival [95,96].