In general, RHAMM is poorly expressed in normal tissues [61], but expression of the full-length protein and isoforms are dramatically and transiently increased during tissue response to injury [14,24,62], and these are constitutively increased with diseases such as breast cancer, multiple myeloma, and bronchopulmonary dysplasia [24,62,63]. The gene discussed is HMMR; the disease is AL amyloidosis.