However, in the case of pancreatic cancer, the dominance of a pro- or anti-tumor effect of RHAMM may also be influenced by Rhamm-loss in the tumor microenvironment [7], in addition to its intrinsic consequences to tumor cell functions, which will affect cancer-associated fibroblasts and immune cell tumorigenic functions. The gene discussed is HMMR; the disease is familial pancreatic carcinoma.